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Several studies have shown that the first step in GSH synthesis involves the formation of -Glu-Cys in an ATP-dependent reaction catalyzed by GCL, which requires Mg 2+ or Mn 2+ as cofactors (Liu et al., 2021)

[DOI] [PubMed] [Google Scholar] [99].Merry TL, Tran M, Dodd GT, Mangiafico SP, Wiede F, Kaur S, McLean CL, Andrikopoulos S, Tiganis T, Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

Approaches such as time-restricted feeding, exercise, natural antioxidant-rich diets, and sleep hygiene practices may act synergistically to support mitochondrial health and promote healthy aging

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